Overload of the liver from excessive fructose intake. Fructose acts like alchol in our body’s metablic pathways. Too much fructose can be a hindrance… see this lecture from a world renowned Paediatrician from UCLA
Check out this clip here for a serious lecture on this matter.
Robert H. Lustig, MD, UCSF Professor of Pediatrics in the Division of Endocrinology, explores the damage caused by sugary foods. He argues that fructose (too much) and fiber (not enough) appear to be cornerstones of the obesity epidemic through their effects on insulin.